Lamotrigine acts on the sodium channels in the brain, inhibiting the excessive electrical activity that leads to seizures and stabilizing mood swings in bipolar disorder. Its efficacy across a wide range of seizure types and its utility in the preventive treatment of bipolar depression highlight its versatility as a medication. Lamotrigine’s distinctive mechanism, coupled with a generally favorable side effect profile, contributes to its effectiveness and tolerability among diverse patient populations.

SKU: N/A Category:


Lamotrigine is an anticonvulsant medication widely prescribed for the management of seizures in patients with epilepsy and for stabilizing mood in individuals with bipolar disorder. Unlike traditional anticonvulsant drugs, lamotrigine has a unique mechanism of action, inhibiting the release of glutamate (an excitatory neurotransmitter) and stabilizing neuronal membranes. This dual action not only helps in controlling epileptic seizures but also effectively manages bipolar disorder’s depressive episodes without inducing mania, making it a preferred choice for patients with this condition.

Additional information



Lamotrigine is indicated for:

● The treatment of partial seizures, primary and secondary tonic-clonic seizures, and the seizures associated with Lennox-Gastaut syndrome in adults and children.
● Maintenance therapy for bipolar I disorder to delay the time to the occurrence of mood episodes in adults aged 18 and older experiencing predominantly depressive episodes.

Patients are advised to:

● Follow the dosing instructions provided by their healthcare provider strictly.
● Be aware of the potential for serious skin rashes and report any skin changes to a healthcare provider immediately.
● Slowly titrate up under the guidance of a healthcare provider to minimize the risk of side effects.


● Taken orally, with or without food.
● The dosage is carefully adjusted according to the patient’s response and presence of side effects.


● Patients with a history of allergy to lamotrigine or its components should not use this medication.
● Lamotrigine may cause severe skin reactions, especially when the initial dosage titration is not followed properly.
● Inform healthcare providers about all medications being taken, as lamotrigine can interact with other drugs, altering its plasma levels.

Drug Interactions:

● Lamotrigine's metabolism can be affected by other medications, either increasing its toxicity or reducing its effectiveness.
● Valproate significantly increases the concentration of lamotrigine, while phenytoin, carbamazepine, phenobarbital, and primidone decrease its levels.

Side Effects

● Dizziness
● Headache
● Double vision
● Nausea
● Fatigue

Serious side effects that require immediate medical attention:

● Skin rash
● Stevens-Johnson syndrome
● Toxic epidermal necrolysis
● Aseptic meningitis
● Blood dyscrasias


● Lamotrigine should be stored at room temperature, away from light and moisture.
● Keep this medication in its original packaging to protect it from exposure to light.

Special Precautions

Before using lamotrigine, patients should inform their healthcare provider if they:

● Have a history of allergy or sensitivity to lamotrigine or other seizure medications.
● Have a history of depression, suicidal thoughts, or mood disorder.
● Are pregnant, planning to become pregnant, or breastfeeding, as lamotrigine can pass through breast milk.


An overdose of lamotrigine can be serious. Symptoms of an overdose may include increased seizures, loss of coordination, blurred vision, and unconsciousness. Immediate medical attention is necessary in the event of an overdose.


There are no reviews yet.

Be the first to review “Lamotrigine”

Your email address will not be published. Required fields are marked *